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ProTx II
CAS No. 484598-36-9
ProTx II( —— )
Catalog No. M30379 CAS No. 484598-36-9
Selective NaV1.7 channel blocker. Shifts activation gating positively and decreases current magnitude. Displays 100-fold selectivity over other sodium channel subtypes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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Biological Information
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Product NameProTx II
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NoteResearch use only, not for human use.
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Brief DescriptionSelective NaV1.7 channel blocker. Shifts activation gating positively and decreases current magnitude. Displays 100-fold selectivity over other sodium channel subtypes.
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DescriptionSelective NaV1.7 channel blocker. Shifts activation gating positively and decreases current magnitude. Displays 100-fold selectivity over other sodium channel subtypes.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetSodium Channel
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RecptorIC50: 0.3 nM (V1.7), 41 nM (v1.2), 102 nM (V1.3), 39 nM (V1.4), 79 nM (V1.5), 26 nM (V1.6), 146 nM (V1.8)
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Research Area——
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Indication——
Chemical Information
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CAS Number484598-36-9
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Formula Weight3826.59
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Molecular FormulaC168H250N46O41S8
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameSequence:{Tyr}{Cys}{Gln}{Lys}{Trp}{Met}{Trp}{Thr}{Cys}{Asp}{Ser}{Glu}{Arg}{Lys}{Cys}{Cys}{Glu}{Gly}{Met}{Val}(Disulfide bridge:Cys2-Cys16;Cys9-Cys21;Cys15-Cys25)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
Tanaka K, et al. Antihyperalgesic effects of ProTx-II, a Nav1.7 antagonist, and A803467, a Nav1.8 antagonist, in diabetic mice. J Exp Pharmacol. 2015 Jun 24;7:11-6.
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