Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - Sodium Channel - ProTx II

ProTx II

CAS No. 484598-36-9

ProTx II( —— )

Catalog No. M30379 CAS No. 484598-36-9

Selective NaV1.7 channel blocker. Shifts activation gating positively and decreases current magnitude. Displays 100-fold selectivity over other sodium channel subtypes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    ProTx II
  • Note
    Research use only, not for human use.
  • Brief Description
    Selective NaV1.7 channel blocker. Shifts activation gating positively and decreases current magnitude. Displays 100-fold selectivity over other sodium channel subtypes.
  • Description
    Selective NaV1.7 channel blocker. Shifts activation gating positively and decreases current magnitude. Displays 100-fold selectivity over other sodium channel subtypes.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    IC50: 0.3 nM (V1.7), 41 nM (v1.2), 102 nM (V1.3), 39 nM (V1.4), 79 nM (V1.5), 26 nM (V1.6), 146 nM (V1.8)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    484598-36-9
  • Formula Weight
    3826.59
  • Molecular Formula
    C168H250N46O41S8
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    Sequence:{Tyr}{Cys}{Gln}{Lys}{Trp}{Met}{Trp}{Thr}{Cys}{Asp}{Ser}{Glu}{Arg}{Lys}{Cys}{Cys}{Glu}{Gly}{Met}{Val}(Disulfide bridge:Cys2-Cys16;Cys9-Cys21;Cys15-Cys25)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Tanaka K, et al. Antihyperalgesic effects of ProTx-II, a Nav1.7 antagonist, and A803467, a Nav1.8 antagonist, in diabetic mice. J Exp Pharmacol. 2015 Jun 24;7:11-6.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Pramoxine hydrochlor...

    Pramocaine hydrochloride is a topical anesthetic, and used as an antipruritic.

  • BI 01383298

    BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).

  • Cariporide

    Cariporide (HOE642)is a potent, selective sodium-hydrogen exchange subtype 1 (NHE1) inhibitor with IC50 of 50 nM.

Sign In Join Free